Rajib B. Profile

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$850 USD / hour

richland,

united states

$850 USD / hour

It's currently 3:37 AM here

Joined May 9, 2016

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Rajib B.

@rbiswasphd

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(0 reviews)

0.0

$850 USD / hour

richland,

united states

$850 USD / hour

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Founder & CEO, CytoHub | Regen Med | Cell Therapy

Dr. Biswas is a visionary leader whose mission is to revolutionize the field of medicine and eradicate suffering on a global scale. With an unwavering commitment to advancing cell therapy and regenerative medicine, Dr. Biswas is a force to be reckoned with in the industry. Dr. Biswas worked as a biotech executive with 18+ years of experience in developing innovative technologies with the last decade's focus on cell-based therapies and platforms to improve human health. Proven expertise in technical operations and CMC of cell-based drug products, CMO selection, tech transfer, supply chain network development, quality control, and material risk assessment. Ph.D. and Postdoctoral training in Bioproducts, Sciences, and Engineering, with diverse experience in implementing state-of-the-art technologies. Strong leadership qualities, with a track record of hiring, developing, and managing high-performing teams of scientists and engineers. Passionate about building organizations to deliver next-generation cell and gene therapies and transforming treatment paradigms.

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Biotech and pharmaceutical companies currently rely on cell culture and manufacturing process that involves managing multiple variables, relying on limited data interpretation, manually sampling and operating the process, and visually monitoring the process. The process lacks a detailed recording of variables that can potentially impact the product outcome, and it relies heavily on the operator's judgment. As a result, it is difficult to consistently produce high-quality and reproducible cell therapy products. CytoHub, Inc. intentionally addresses the challenges with the application of AI.

Sale-up || Cell Therapy and Regenerative Medicine

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Experience

Washington State University, USA

Sep 2013 - Present

I have been involved in multiple projects including National Advanced Biofuels Consortium (NABC); Northwest Advanced Renewables Alliance (NARA, www.nararenewables.org); MYCO-fuels and MYCO-chemicals: Consolidated bioprocessing of biomass into advanced fuels and high value compounds in fungal cell factories; AD of HTL Algal Wastewater. Funding sources: USDA, DOE, PNNL, EU.

Linköping University, Sweden

Jun 2009 - Present

The transition period between my Masters and PhD was devoted to conduct research under the supervision of Prof. Bo Svensson where I conceptualized efficient utilization of household wastes for bioenergy production including: Ø Conducted experiments on greenhouse gas emission due to natural aerobic degradation of household waste and environmental impact assessment. Ø Studied biochemical methane potential assays for renewable methane production from household waste.

CytoHub, Inc.

Mar 2022 - Present

Cytohub is a cutting-edge biotech firm specializing in advanced cell and gene therapy development using AI and platform technology. • Acting as Company-Builder-in-Chief, responsible for hiring leadership team, developing business plan, creating purpose and alignment, and negotiating terms and conditions licensing agreement. • Executing mission to revolutionize regenerative medicine by using AI/ML to improve hSCs, HSPCs, iPSC-derived cells, NK cells, and CAR-T cells for treating various diseases.

Education

Postdoctoral Research, Biochemical Engineering

Washington State University,

United States

2012 - 2016

(4 years)

PhD, Biotechnology, Chemistry and Environmental Engineering

Aalborg Universitet,

Denmark

2009 - 2012

(3 years)

M.Sc, Environmental Science

Linköpings universitet,

Sweden

2006 - 2009

(3 years)

Publications

Biomethanation of red algae from the eutrophied Baltic Sea

Department of Water and Environmental Studies, Linköping University, Sweden (2009)

In the semi-enclosed Baltic Sea, excessive filamentous macro-algal biomass growth as a result of eutrophication is an increasing environmental problem. Drifting huge masses of red algae of the genera Polysiphonia, Rhodomela, and Ceramium accumulate on the open shore, up to five tones of algae per meter beach. During the aerobic decomposition of these algal bodies, large quantities of red colored effluents leak into the water what are toxic for the marine environment.

Increasing the biogas yield of manure by wet explosion of the digested fiber fraction

12th World Congress on Anaerobic Digestion (2010), Guadalajara, Mexico

Increasing the biodegradability of the lignocellulosic fiber fraction of manure can ensure higher methane productivity in biogas plants, leading to process profitability and thus larger production of renewable energy. A new pretreatment method, wet explosion (WEx), was investigated to treat digested manure fibers from the effluent of an anaerobic digester for enhancing biogas production and exploring the untapped biomass potential.

Improving biogas yields using an innovative pretreatment concept for conversion of the fiber

International Symposium on AD of Solid Waste and Energy Crops (2011), Vienna, Austria

A new concept to enable economically feasible operation of manure based biogas plants was tested in lab-scale. Wet explosion (WEx) was implemented as treatment of the residual manure fibers separated after the anaerobic digestion process for enhancing the biogas production before reintroducing into the biogas reactor.

FiberMaxBiogas– a new concept for improving the economy of manure based biogas plants

Nordic Biogas Conference (2012), April 23–25, Copenhagen, Denmark

The FiberMaxBiogas project investigates a new concept of combining the biogas process and wet explosion (WEx) treatment in order to achieve economically feasible biogas production from manure alone. The WEx treatment is applied to the fiber fraction separated from the effluent of the biogas reactor.

Improving biogas yields using an innovative concept for conversion of the fiber fraction of manure

Water Science and Technology (2012) 66 (8), 1751-1758

The potential of a new concept to enable economically feasible operation of manure-based biogas plants was investigated at laboratory scale. Wet explosion (WEx) was applied to the residual manure fibers separated after the anaerobic digestion process for enhancing the biogas yield before reintroducing the fiber fraction into the biogas reactor. The increase in methane yield of the digested manure fibers was investigated by applying the WEx treatment under five different process conditions.

Optimization of the wet explosion pretreatment for increasing biogas and bioethanol yield

Dept. of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Denmark (2012)

This dissertation represents a culmination of research work and learning that has taken place over the past few years (2009-2012). The experimental work of this dissertation has been initiated at the Section for Sustainable Biotechnology, Aalborg University Copenhagen in September 2009. Since February 2011, the rest of the research based on pilot-scale experimental work has been conducted at the Bioproducts, Sciences, and Engineering Laboratory, Washington State University, USA.

Key factors for achieving profitable biogas production from agricultural waste

World Congress on Anaerobic Digestion 2013

Based on numerous investigations on increasing the biogas yield of manure, a new concept was developed to increase the economical operation of manure based biogas plants by combining up concentration of manure with a more specific treatment of the recalcitrant lignocellulosic fiber fraction by implementing the treatment on the digested solid fraction. Catch crops have been identified as a sustainable co-substrate for biogas production with a high biogas potential.

Conversion of C6 and C5 sugars in undetoxified bagasse hydrolysates using Pichia stipitis

AMB Express (2013) 3 (1), 1-7

Sugarcane bagasse is a potential feedstock for cellulosic ethanol production, rich in both glucan and xylan. During processing of the hydrolysate degradation products such as acetate, 5-hydroxymethylfurfural (HMF) and furfural are formed, which are known to inhibit microbial growth at higher concentrations. Conversion of both glucose and xylose sugars into ethanol in wet exploded bagasse hydrolysates was investigated without detoxification using Scheffersomyces (Pichia) stipitis CBS6054.

Wet explosion pretreatment of sugarcane bagasse for enhanced enzymatic hydrolysis

Biomass and Bioenergy (2015) 61, 104-113

Highlights • Wet explosion pretreatment of sugarcane bagasse was investigated in pilot-scale. • Temperatures used were 155, 170, 185 and 200 °C with or without oxygen. • Pretreatment conditions at 185 °C with oxygen (0.6 MPa) found optimal. • Only 22.0 g kg−1 (as enzyme protein on cellulose) was used to enhance the hydrolysis. • Glucose yield was 87.4 ± 0.7% of the theoretical maximum at optimal conditions.

Wet Explosion: a Universal and Efficient Pretreatment Process for Lignocellulosic Biorefineries

BioEnergy Research (2015) 8 (3), 1101-1116

Lignocellulosic biomass resources especially agricultural and forests residues, perennial crops, farm wastes, and the organic fraction of municipal solid waste hold significant potential for the widespread production of sustainable fuels, chemicals, and bioproducts worldwide. Presented here is a summary of the basic concepts and parameters involved in WEx pretreatment.

Making lignin accessible for anaerobic digestion by wet-explosion pretreatment

Bioresource technology (2015) 175, 182-188

Highlights • The pretreatment of feedlot manure was performed using 4 bars oxygen. • Oxygen assisted wet-explosion pretreatment promotes lignin solubility. • 4.5 times higher methane yield observed as a result of the pretreatment. • 44.4% lignin in pretreated material was actually converted in the AD process. • Aliphatic compounds formed in the pretreatment were utilized by microbes.

Pretreatment of forest residues of Douglas fir by wet explosion...

Bioresource technology (2015) 192, 46-53

Highlights • The pretreatment of forest residues was performed by wet explosion at pilot-scale. • Process conditions were optimized using an experimental design. • Maximum digestibility achieved at 190 °C, time 30 min, and oxygen loading of 7.5%. • Glucose yield at optimal pH of 5.5 was 63.3% of the theoretical maximum. • A recovery of cellulose and lignin of 99.9% and 96.3%, respectively, was achieved.

Chapter 16. Fractionation of Lignocellulosic Biomass Materials With Wet Explosion Pretreatment

Elsevier (2016) - ISBN: 978-0-12-802323-5

Biomass Fractionation Technologies for a Lignocellulosic Feedstock-based Biorefinery reviews the extensive research and tremendous scientific and technological developments that have occurred in the area of biorefinering, including industrial processes and product development using ‘green technologies’, often referred as white biotechnology.